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CYCLIC PALLADIUM COMPOUNDS HAVING COORDINATED THERETO BIS (DIPHENYLPHOSPHINE) FERROCENE LIGANDS WHICH INHIBIT THE ACTIVITY OF PROTEINS AND ENZYMES AND TREATMENT OF DISEASES AND DISORDERS ASSOCIATED THEREWITH 

Document type:Patente
Inventor(s): Antonio Carlos Fávero Caires; Claudia Bincoletto Trindade; Ivarne Luis Dos Santos Tersariol
Applicant: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Deposit date: July 2007, 13
INPI register:
US11/777,604
IPC: A61K 31/28 C07F 15/00
Abstract

The invention relates to cyclopalladated compounds containing bis-diphenylphosphine-ferrocene ligands and their analogues which are active inhibitors of proteins and enzymes, for example, those of the serine peptidase, cysteine-protease, metalo-protease and endopeptidase families, involved in the development and metastases of malignant tumors, e.g. of the thyroid. An exemplary compound is shown in the figure. The compounds are able to modulate the immunological system due to their action on the enzymes and their interaction with DNA molecules.


Grantee:Antonio Carlos Fávero Caires
Principal Investigator:Antonio Carlos Fávero Caires
Institution: Universidade de Mogi das Cruzes (UMC). Centro de Ciências Exatas e Tecnologia
Support Opportunities: Research Grants - Young Investigators Grants

Grantee:Andrea Licia de Almeida Oliveira
Principal Investigator:Andrea Licia de Almeida Oliveira
Institution: Universidade de Mogi das Cruzes (UMC). Campus da Sede Mogi das Cruzes
Support Opportunities: Research Grants - Support for Intellectual Property Rights and Licensing (PAPI/Nuplitec)