Company research projects supported by PIPE Program

• Abstract

  The medullary thyroid carcinoma (MTC), although rarer than others differentiated thyroid carcinomas (around 3-4% cases), exhibits more aggressive behaviour, with mortality rate over 50% in late diagnosed cases and higher recurrence and metastasis risks even after total thyroidectomy surgery. It can be classified into two subtypes: sporadic (75% cases) and hereditary (25%), with sporadic s…

  MicroRNAs validation as biomarkers for medullary thyroid carcinoma diagnosis, AP.PIPE

• Abstract

  Thyroid nodules may be found by palpation in 1 to 7% of the population. Brazilian and international guidelines recommend that nodes greater than 1 cm in patients with normal thyroid function, should be drained through Fine Needle Aspiration (FNA). About 65 to 80% of punctured nodules are considered benign and 5 to 15% malignant. However, between 15 and 30% are classified as indeterminate …

  Multicentric characterization and validation of a molecular diagnostic test for the classification of indeterminate thyroid nodules based on microRNA profiling, AP.PIPE

• Abstract

  The prostate cancer is the second most common among men in Brazil (approximately 28% of cases) and in recent years there was an increase in incidence, with high mortality rate. Guidelines established by the Brazilian Society of Urology (SBU) recommend that the diagnosis should be predicted after performing rectal (DRE) and prostate-specific antigen (PSA). The definitive diagnosis is made …

  MicroRNA profiling as an identification tool of recurrence on prostate cancer patients, AP.PIPE

(Only some records are available in English at this moment)