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Potential impact of bariatric surgery on periodontal health in obese subjects. Determining the microbiological and immunological profile.

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Author(s):
Sheila Alexandra Belini Nishiyama
Total Authors: 1
Document type: Doctoral Thesis
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:
Examining board members:
Mario Julio Avila Campos; Joni Augusto Cirelli; Waldir Pereira Elias Junior; Francisco Carlos Groppo; Fabio Daumas Nunes
Advisor: Mario Julio Avila Campos
Abstract

In this study, the aimed to evaluate the subgingival microbiota using Checkerboard technique and the cytokines profile by using immunoassay based on the flowmetry gingival fluid and serum in non-obese and obese individuals, before and after bariatric surgery. Differences were observed in the oral microbiota between nonobese and obese for 19 bacterial species, particularly E. corrodens that showed significant differences in obese, with a consequent reduction after weight loss. The cytokines IL-1b, IL-6, IL-10, IL-13, IL-17, TNF-a, leptin and adiponectin were statistically different (p <0.05) when these individuals were compared. All analyzed cytokines in serum decreased after weight reduction only adiponectin concentrations showed significantly higher (p <0.05). Thus, obesity causes changes in the subgingival microbiota and the local immune response, and prevention and control can promote oral health. (AU)

FAPESP's process: 08/09654-5 - POSSIBLE IMPACTS OF GASTRIC SURGERYS ON THE PERIODONTAL MICROBIOTA IN PATIENTS WITH OBESITY: DETERMINATION OF THE MICROBIOLOGICAL AND IMUNOLOGICAL PROFILE
Grantee:Sheila Alexandra Belini Nishiyama
Support type: Scholarships in Brazil - Doctorate