Syinthesis, characterization and study of antibacterial activities of metal complexes of Au(I), Ag(I) and Pd(II) with rimantadine

Rimantadine (C12H21N - rtd) is a antiviral agent which inhibit specifically the replication of the virus influenza A. The presence of group -NH2 confers the ability to coordinate with different metal ions. In this work 3 novel metal complexes of Au(I), Ag(I) e Pd(II) with rimantadine were synthesized. The complexes were prepared by the reaction of aqueous or alcoholic solutions of rimantadine with the respective salts of Au(I), Ag(I) e Pd(II). The compounds were characterized by a set of chemical and spectroscopic analyses, also by Density Functional Theory (DFT) studies. The infrared (IR) spectra and nuclear magnetic resonance (NMR) of the free rtd and of the compounds indicate the coordination of rtd to metallic ions through the nitrogen atom of group NH2. The compounds were analyzed concerning their antibacterial activities against Gram-positive and Gram-negative bacterial strains. The results showed that the Au(I) and Ag(I) complexes are active against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli strains (AU)