Advanced search
Start date

Expression and immune recognition of conserved alleles of Plasmodium falciparum variant antigens.

Full text
Alessandra Sampaio Bassi Fratus
Total Authors: 1
Document type: Master's Dissertation
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:
Examining board members:
Gerhard Wunderlich; Fábio Trindade Maranhão Costa; Marcelo Urbano Ferreira
Advisor: Gerhard Wunderlich

An important factor in the pathogenicity of P. falciparum, the causing agent of malaria is the expression of highly polymorphic antigens encoded by the multigene families var and rif. The extreme polymorphism of these genes in strains from different geographical regions is in contrast with the observation of a number of conserved alleles found in Amazonian isolates. The humoral response against these proteins is considered an important factor in the immunity against symptomatic infection in áreas with high transmission. We measured the antibody response against recombinant PfEMP1 and RIFIN antigens and detected low responsiveness of symptomatic and asymptomatic malaria infected individuals. These responses were not only weak when compared to the anti-merozoite surface protein 1 response, but also ceased rapidly after the removal of circulating parasites. On the basis of these results, the response against DBLa seems to be dependent on the presence of parasites and not important for the observed protection against symptomatic infection in hypoendemic settings. (AU)

FAPESP's process: 06/02143-0 - Conserved alleles in Plasmodium falciparum variant antigens: studies on existence and immunological response in individuals from an endemic area
Grantee:Alessandra Sampaio Bassi Fratus
Support Opportunities: Scholarships in Brazil - Master