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Role of PD-1 and PD-L1 in the regulation of CD4+ and CD8+ T cell responses to blood-stage Plasmodium chabaudi malaria.

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Letícia Sarturi Pereira Severi
Total Authors: 1
Document type: Master's Dissertation
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:
Examining board members:
Maria Regina D'Imperio Lima; Fábio Trindade Maranhão Costa; Ana Paula Lepique
Advisor: Maria Regina D'Imperio Lima

Malaria is responsible to kill over a million people a year worldwide. The complications of the disease in humans infected by parasites of the genus Plasmodium, appears to be to the exacerbated immune response to infection. Inhibitory molecules such as PD-1 and PD-L1 are expressed at high levels in T cells in mice in the acute phase of infection by P. chabaudi. Then, the aim was to examine the role of PD-1 and PD-L1 in the activation and regulation of T spleen cells of mice during acute infection with P. chabaudi. The results show an increase of PD-1 expression in CD4+ T cells, and an increase of PD-L1 expression on T and B cells. We observed the regulatory role of these molecules when we find a lower proliferation of CD4+ T cells expressing PD-1 stimulated with anti-CD3; and also, when we observed a reduction in IFN-<font face=\"Symbol\">g production. Therefore, PD-1 and PD-L1 may be important in the control of immune response during the acute phase of infection, as well as for the generation of more specific response to the chronic phase. (AU)

FAPESP's process: 10/13467-6 - Determination of the Toll like receptor-activated cell producing gamma-interferon during experimental Trypanosoma cruzi infection
Grantee:Letícia Sarturi Pereira Severi
Support type: Scholarships in Brazil - Master