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Comparison of the clinical efficacy of ketoprofen, associated or not with omeprazole, in the control of pain, swelling and trismus in lower third molar removal

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Author(s):
Luis Fernando Simoneti
Total Authors: 1
Document type: Master's Dissertation
Press: Bauru.
Institution: Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB)
Defense date:
Examining board members:
Carlos Ferreira dos Santos; Ana Lucia Alvares Capelozza; Hugo Nary Filho; Sandra Helena Penha de Oliveira
Advisor: Carlos Ferreira dos Santos
Abstract

In view of the gastrointestinal problems generated by the use of ketoprofen, the association of ketoprofen with omeprazole is available on the market. However, the efficacy of this association in the acute control of pain has not been established. Therefore, the objective of the present study was to evaluate the clinical efficacy of therapy performed with ketoprofen 100 mg twice daily versus therapy performed with ketoprofen 200 mg + omeprazole 20 mg once daily, both administered enterally to control pain, swelling and trismus in the bilateral extraction model of lower third molars in similar positions in two different appointments. The present randomized, double-blind, crossover study consisted of 50 volunteers with a mean age of 24 ± 5 years. The paired t test was used for the parametric data expressed as mean ± standard deviation and the Wilcoxon test for non-parametric data expressed as median ± interquartile range. The level of significance was 5%. When volunteers took ketoprofen 200 mg + omeprazole 20 mg once daily, they reported significantly less postoperative pain at various post-operative periods and consumed less rescue analgesic medication (acetaminophen 750 mg) throughout the study compared to ketoprofen 100 mg twice daily. In addition, the evaluations of the drugs in the control of postoperative pain by the volunteers were significantly favorable to ketoprofen 200 mg + omeprazole 20 mg once daily as compared with ketoprofen twice daily. For the control of swelling and trismus, the treatments presented similar results. Therefore, it can be concluded that ketoprofen 200 mg + omeprazole 20 mg once daily presented better results in postoperative pain control after extractions of the lower third molars when compared to ketoprofen 100 mg twice daily. (AU)

FAPESP's process: 14/25792-0 - Comparison of the clinical efficacy of ketoprofen, associated or not with omeprazole, in the control of pain, swelling and trismus in lower third molar removal
Grantee:Luis Fernando Simoneti
Support type: Scholarships in Brazil - Master