Identificação e anotação funcional de novos transcritos com expressão alterada no câncer pancreático

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Identification and functional annotation of novel transcripts with altered expression in pancreatic cancer

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Author(s):	Omar Julio Sosa Total Authors: 1
Document type:	Doctoral Thesis
Press:	São Paulo.
Institution:	Universidade de São Paulo (USP). Instituto de Matemática e Estatística (IME/SBI)
Defense date:	2019-02-27
Examining board members:	Eduardo Moraes Rego Reis; Helena Paula Brentani; Edna Teruko Kimura; Ana Cristina Victorino Krepischi; Israel Tojal da Silva
Advisor:	Eduardo Moraes Rego Reis; João Carlos Setubal
Abstract
In the present work, we applied a bioinformatic pipeline to process and analyse data from total RNA-seq strand-oriented generated in our laboratory from matched samples of tumor and non-tumor adjacent pancreatic tissue from 14 patients with the goal of generate a high resolution catalog of the composition and the alterations in the transcriptome of PDAC, including protein coding and non coding genes. (AU)

FAPESP's process:	13/13350-0 - Implementation of computational analyses to identify novel biomarkers for molecular diagnosis of pancreatic tumors using next generation sequencing data
Grantee:	Omar Julio Sosa
Support Opportunities:	Scholarships in Brazil - Doctorate (Direct)