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AeMOPE-1: a novel salivary immunomodulatory peptide of Aedes aegypti with therapeutic potential in experimental colitis.

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Priscila Guirão Lara
Total Authors: 1
Document type: Doctoral Thesis
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:
Examining board members:
Anderson de Sá Nunes; Claudia Ida Brodskyn de Assis; Anita Mitico Tanaka Azevedo; Daniela Santoro Rosa; Nancy Starobinas
Advisor: Anderson de Sá Nunes

Mosquitoes are the most important vectors of pathogens that causing infectious to humans. To female succeed in their hematophagous habit and thus acquire the nutrients necessary for the maturation of their eggs, their saliva has components with anti-hemostatic and immunomodulatory activities. Thus, the aim of this project was to study the role of a novel salivary peptide described in the A. aegypti sialome, present only in female salivay glands, whose biological functions are still unknown. It was observed that the peptide named AeMOPE-1 inhibited the production of pro-inflammatory mediators by activated macrophages, as well as induced the immune response to the Th2 profile. Treatment with AeMOPE-1 reduced the clinical symptoms of experimental colitis. This works presents the first salivary peptide from A. aegypti with potent activity on macrophage biology and potential clinical application. (AU)

FAPESP's process: 13/00740-4 - Salivary peptides of Aedes aegypti
Grantee:Priscila Guirão Lara
Support type: Scholarships in Brazil - Doctorate