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Analysis of the haemoglobin catabolism of Plasmodium falciparum.

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Author(s):
Jasmin Lindner
Total Authors: 1
Document type: Doctoral Thesis
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:
Examining board members:
Carsten Wrenger; Letusa Albrecht; Giuseppe Palmisano; Renata Rosito Tonelli
Advisor: Carsten Wrenger
Abstract

The metabolism of nutrients harbors a high potential for the development of new chemotherapeutic targets for the treatment of the malaria parasite Plasmodium falciparum. From parasite growth assays within genetically different erythrocytes, concentrating on the catabolic pathway of plasmodial hemoglobin using transgenic parasites, the protective nature of hemoglobin variants was investigated. Since Falcipain 2 (FP2) proliferates three times higher in sickle cell blood than the Mock, the control cell. In addition, inhibitor studies indicate that FP2 is an essential protein for the parasite. In cooperation with DESY in Hamburg, Germany the crystalline structure of the amino peptidase P was resolved diffracting up to 1.7 Å. (AU)

FAPESP's process: 12/12790-3 - Analysis of the haemoglobin catabolism of Plasmodium falciparum proliferation in genetically modified erythrocytes
Grantee:Jasmin Lindner
Support type: Scholarships in Brazil - Doctorate