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Identification of Toxoplasma gondii fetuin-binding protein

Grant number: 05/00479-8
Support Opportunities:Scholarships abroad - Research
Effective date (Start): June 01, 2005
Effective date (End): August 31, 2005
Field of knowledge:Biological Sciences - Immunology - Immunochemistry
Principal Investigator:Ademilson Panunto-Castelo
Grantee:Ademilson Panunto-Castelo
Host Investigator: Michael Anthony John Ferguson
Host Institution: Pessoa Física
Research place: University of Dundee, Scotland  


Preliminary results of our group suggest that Toxoplasma gondii tachyzoites present a fetuin-binding protein (Fet-BP) with apparent molecular mass of 80-kDa. Fet-BP was recovered in the buffer acid-eluted fraction upon affinity chromatography on immobilised fetuin column of the soluble antigen fraction from tachyzoites of the virulent RH strain that was previously depleted of lactose binding proteins on alpha-lactose-column. Since Fet-BP can bind to fetuin through glycan recognition, we suppose that it can play a key role in the invasion process events. This project aims identify Fet-BP to determine its biological role concerning to interaction between T. gondii and host cell. (AU)

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