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Dipteryx alata Vogel: antiophidian action and toxicity

Grant number: 08/11005-5
Support Opportunities:Scholarships abroad - Research
Effective date (Start): September 01, 2009
Effective date (End): December 31, 2009
Field of knowledge:Biological Sciences - Pharmacology - Autonomic Pharmacology
Principal Investigator:Yoko Oshima Franco
Grantee:Yoko Oshima Franco
Host Investigator: Arturo San Feliciano Martin
Host Institution: Pró-Reitoria de Pós-Graduação e Pesquisa. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil
Research place: Universidad de Salamanca (USAL), Spain  

Abstract

Previously our study with barks hydroalcoholic extract from Dipteryx alata Vogel showed an antiophidian property against the neuromuscular blockade induced by Bothrops jararacussu snake venom. Our objectives are: 1) To obtain extracts of different polarities (hexane, dichloromethane, ethyl acetate and methanol) from barks of D. alata; 2) To identify the extract responsible by antineurotoxic action of two crude venoms: Bothrops jararacussu e Crotalus durissus terrificus, under myographical and histological parameters; 3) To obtain the fractions from active extract and to identify the compound(s); and 4) To assay embryotoxicity, citotoxicity (chinese hamster ovary) and mutagenicity (Ames test) from hydroalcoholic extract. The data will be statistically analysed by t-Student test. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FONTANA OLIVEIRA, ISADORA CARUSO; DE PAULA, MARINA OLIVEIRA; BOSCHILHA LASTRA, HELLEN CRISTINE; ALVES, BRUNO DE BRITO; NETO MORENO, DEBORA ANTUNES; YOSHIDA, EDSON HIDEAKI; AMARAL FILHO, JORGE; COGO, JOSE CARLOS; VARANDA, ELIANA APARECIDA; RAI, MAHENDRA; et al. Activity of silver nanoparticles on prokaryotic cells and Bothrops jararacussu snake venom. DRUG AND CHEMICAL TOXICOLOGY, v. 42, n. 1, p. 60-64, . (08/11005-5, 15/01420-9, 12/08271-0)
FERRAZ, MIRIELE CRISTINA; DE OLIVEIRA, JHONES LUIZ; DE OLIVEIRA JUNIOR, JOEL REIS; COGO, JOSE CARLOS; DOS SANTOS, MARCIO GALDINO; FRANCO, LUIZ MADALENO; PUEBLA, PILAR; FERRAZ, HELENA ONISHI; FERRAZ, HUMBERTO GOMES; TEIXEIRA DA ROCHA, MARISA MARIA; et al. The Triterpenoid Betulin Protects against the Neuromuscular Effects of Bothrops jararacussu Snake Venom In Vivo. Evidence-based Complementary and Alternative Medicine, . (08/11005-5)
FERRAZ, MIRIELE CRISTINA; CELESTINO PARRILHA, LUCIANE APARECIDA; DUARTE MORAES, MARIA SILVIA; AMARAL FILHO, JORGE; COGO, JOSE CARLOS; DOS SANTOS, MARCIO GALDINO; FRANCO, LUIZ MADALENO; GROPPO, FRANCISCO CARLOS; PUEBLA, PILAR; SAN FELICIANO, ARTURO; et al. The Effect of Lupane Triterpenoids (Dipteryx alata Vogel) in the in vitro Neuro-muscular Blockade and Myotoxicity of two Snake Venoms. CURRENT ORGANIC CHEMISTRY, v. 16, n. 22, p. 2717-2723, . (08/11005-5)
TRIBUIANI, NATALIA; DA SILVA, ALEXANDRO MATEUS; FERRAZ, MIRIELE CRISTINA; SILVA, MAGALI GLAUZER; GUERREIRO BENTES, ANA PAULA; GRAZIANO, TALITA SIGNORETI; DOS SANTOS, MARCIO GALDINO; COGO, JOSE CARLOS; VARANDA, ELIANA APARECIDA; GROPPO, FRANCISCO CARLOS; et al. Vellozia flavicans Mart. ex Schult. hydroalcoholic extract inhibits the neuromuscular blockade induced by Bothrops jararacussu venom. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v. 14, . (08/11005-5, 12/08271-0)
YOSHIDA, EDSON H.; TRIBUIANI, NATALIA; FORAMIGLIO, AMERIS L.; FORAMIGLIO, CAROLINE A.; DA SILVA TAVARES, RENATA V.; BONOMINI, TIAGO J.; BUENO, PAULA C. P.; CAVALHEIRO, ALBERTO J.; HYSLOP, STEPHEN; PUEBLA, PILAR; et al. A Highly Polar Phytocomplex Involving Rutin is Responsible for the Neuromuscular Facilitation Caused by Casearia sylvestris (guacatonga). CURRENT PHARMACEUTICAL BIOTECHNOLOGY, v. 17, n. 15, p. 1360-1368, . (08/11005-5, 12/08271-0)
PUEBLA, PILAR; OSHIMA-FRANCO, YOKO; FRANCO, LUIZ M.; DOS SANTOS, MARCIO G.; DA SILVA, RENATA V.; RUBEM-MAURO, LEANDRO; SAN FELICIANO, ARTURO. Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom. Molecules, v. 15, n. 11, p. 8193-8204, . (08/11005-5)
WERNER, ADRIANA C.; FERRAZ, MIRIELE C.; YOSHIDA, EDSON H.; TRIBUIANI, NATALIA; GAUTUZ, JEAN A. A.; SANTANA, MONIQUE N.; DEZZOTTI, BRUNA A.; DE MIRANDA, VANESSA G.; FORAMIGLIO, AMERIS L.; ROSTELATO-FERREIRA, SANDRO; et al. The Facilitatory Effect of Casearia sylvestris Sw. (guacatonga) Fractions on the Contractile Activity of Mammalian and Avian Neuromuscular Apparatus. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, v. 16, n. 5, p. 468-481, . (08/11005-5, 12/08271-0)
YOSHIDA, EDSON HIDEAKI; TRIBUIANI, NATALIA; SABADIM, GIOVANA; NETO MORENO, DEBORA ANTUNES; VARANDA, ELIANA APARECIDA; OSHIMA-FRANCO, YOKO. Evaluation of Betulin Mutagenicity by Salmonella/Microsome Test. ADVANCED PHARMACEUTICAL BULLETIN, v. 6, n. 3, p. 443-447, . (08/11005-5, 12/08271-0)
FERRAZ, MIRIELE C.; YOSHIDA, EDSON H.; TAVARES, RENATA V. S.; COGO, JOSE C.; CINTRA, ADELIA C. O.; DAL BELO, CHARISTON A.; FRANCO, LUIZ M.; DOS SANTOS, MARCIO G.; RESENDE, FLAVIA A.; VARANDA, ELIANA A.; et al. An Isoflavone from Dipteryx alata Vogel is Active against the in Vitro Neuromuscular Paralysis of Bothrops jararacussu Snake Venom and Bothropstoxin I, and Prevents Venom-Induced Myonecrosis. Molecules, v. 19, n. 5, p. 5790-5805, . (08/11005-5)
NETO MORENO, DEBORA ANTUNES; SALADIN, MIRELA SANTOS; MARQUES VIROEL, FABIA JUDICE; JUSTE DINI, MURILO MELO; PICKIER, THAISA BORIM; AMARAL FILHO, JORGE; DOS SANTOS, CAROLINA ALVES; HANAI-YOSHIDA, VALQUIRIA MIWA; GROTTO, DENISE; GERENUTTI, MARLI; et al. Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats. ADVANCED PHARMACEUTICAL BULLETIN, v. 11, n. 1, p. 130-136, . (12/08271-0, 15/01420-9, 08/11005-5)

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