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Multi-locus candidate gene polymorphisms and risk of type 2 Diabetes Mellitus: population-based, prospective genetic analysis

Grant number: 08/00676-6
Support Opportunities:Scholarships abroad - Research
Effective date (Start): April 01, 2008
Effective date (End): August 31, 2008
Field of knowledge:Health Sciences - Collective Health
Principal Investigator:Alessandra Carvalho Goulart
Grantee:Alessandra Carvalho Goulart
Host Investigator: Kathryn M. Rexrode
Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Research place: Harvard University, Boston, United States  


Type 2 diabetes (T2D) is a complex disease characterized by insulin resistance and impaired pancreatic ²-cell function. In T2DM, a variety of environmental and genetic factors play a major role in the clinical expression of disease. The most frequent form of the disease is late onset T2DM, which may be characterized by a polygenic syndrome. Polymorphisms in candidate genes associated with glucose homeostasis, lipids metabolism, cardiovascular risk factors or pro-inflammatory cytokines may represent potential risk factors to T2DM. The aim of this study was to assess the relationship between a panel of well characterized genetic variants in 36 candidate genes and the incidence of type 2 diabetes mellitus. We evaluated a panel of 55 candidate genes polymorphisms in a total of 24,309 Caucasian women free of diabetes at baseline, who have participated of the Women's Health Study during median follow up of 10 years. Cox proportional-hazards models were constructed to compared the incidence of T2DM according to the different genotypes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAGE-WILSON, GABRIELLE; GOULART, ALESSANDRA C.; REXRODE, KATHRYN M.. Interrelation Between Sex Hormones and Plasma Sex Hormone-Binding Globulin and Hemoglobin A1c in Healthy Postmenopausal Women. METABOLIC SYNDROME AND RELATED DISORDERS, v. 7, n. 3, p. 249-254, . (08/00676-6)
GOULART, ALESSANDRA C.; ZEE, ROBERT Y. L.; PRADHAN, ARUNA; REXRODE, KATHRYN M.. Associations of the Estrogen Receptors 1 and 2 Gene Polymorphisms With the Metabolic Syndrome in Women. METABOLIC SYNDROME AND RELATED DISORDERS, v. 7, n. 2, p. 111-117, . (08/00676-6)

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