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Reinstatement of nicotine-conditioned place preference (CPP) induced by nicotine and stress

Grant number: 05/02336-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2005
Effective date (End): October 31, 2008
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal researcher:Cleopatra da Silva Planeta
Grantee:Rodrigo Molini Leão
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Tobacco is currently the most widely used drug in the world. Pre-clinical and clinical studies show that nicotine is the substance responsible for tobacco addiction. High rates of relapse are common in people trying to abstain from tobacco use. Several factors have been shown to be associated with relapse, including exposure to tobacco and stress. Animal models that help elucidate the variables controlling the relapse to smoking may be helpful in developing better relapse prevention techniques to achieve long-term smoking abstinence. One animal model considered suitable for studying relapse phenomena is the reinstatement of conditioning place preference (CPP) after the extinction of the conditioned behavior. Although this paradigm has been widely used to study relapse to psychostimulant and opioids, there is a limited number of studies on nicotine-induced reinstatement of CPP. The purpose of the present project is to investigate reinstatement of nicotine-induced CPP following the priming injection nicotine or after exposure to stress. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEAO, RODRIGO M.; CRUZ, FABIO C.; PLANETA, CLEOPATRA S.. Exposure to acute restraint stress reinstates nicotine-induced place preference in rats. Behavioural Pharmacology, v. 20, n. 1, p. 109-113, . (05/02336-0)
RODRIGO M LEÃO; FÁBIO C CRUZ; CLEOPATRA S PLANETA. Prior exposure to stress delays extinction but does not modify reinstatement of nicotine-induced conditioned place preference. Psychology & Neuroscience, v. 3, n. 1, p. 53-57, . (05/02336-0)

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