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Medicinal chemistry: synthesis and bioactivity of metalized organo chalcones with transition elements and related compounds

Grant number: 05/04538-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2006
Effective date (End): April 30, 2007
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Alberto Federman Neto
Grantee:Cláudio Battiston Loureiro
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Synthesis of new (and improvements in the synthesis or some recently described) bioactive organometallic ferrocenyl chalcones, based on the modifications of the classical Claisen-Schmidt aldol condensation. The new methodologies were developed bi variation of the nature of the catalytic base employed, variation of the reactions conditions and use of unsual methodologies as ultrasound, microwave irradiation etc... (AU)

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