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A new approach for dihydro-isoquinolinones and tetra-isoquinolines preparation from Morita-Baylis-Hillman adducts

Grant number: 06/04767-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2006
Effective date (End): November 30, 2007
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Fernando Antonio Santos Coelho
Grantee:Michele Fernanda Lino de Souza
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This project for an undergraduate student has as proposal the preparation of dihydroisoquinolinones and tetrahydroisoquinolines from Morita-Baylis-Hillman adducts using a new synthethic approach. This approach is based on the utilization of a ozonolyis reaction of the silylated adducts, followed by a reductive amination step. (AU)

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