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Temporal and spatial genes expression (Ras, Myc, Fos, Jun and Msx2) and their transcription factors regulated by matrix metalloproteinases, their tissue inhibitors and RECK during mouse endochondral ossification

Grant number: 07/00216-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2007
Effective date (End): July 31, 2010
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Fabio Daumas Nunes
Grantee:Katiúcia Batista da Silva Paiva
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


MMPs are zinc-dependent endopeptidases that, collectivelly, degrade all components of the ECM. They are able to remodelate the ECM during normal developmental processes such as embryogenesis and organogenesis, as well as in pathological processes such as tumoral invasion. The biological mineralization research looking for discovering the genes involved in the molecular mechanisms that control the endochondral ossification process. MMPs and their inhibitors (TIMPs and RECK) are responsable for bone matrix remodeling and, probably, determinate the level of its turnover. Msx2 is a homeobox-contains gene important for a limb development. Thus, our goal is evaluating the temporal-spatial genes expression (Ras, Myc, Jun, Fos and Msx2) and their transcription factors regulated by RECK, MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, TIMP-3 and TIMP-4 in mice embryos and newborns during endochondral ossification by molecular biology (in situ hybridization and Real-Time PCR), immunoassay (immunohistochemistry and western blot), and biochemistry techniques (gelatin zymography).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA PAIVA, KATIUCIA BATISTA; ZAMBUZZI, WILLIAN FERNANDO; ACCORSI-MENDONCA, THAIS; TAGA, RUMIO; NUNES, FABIO DAUMAS; SOGAYAR, MARI CLEIDE; GRANJEIRO, JOSE MAURO. Rat forming incisor requires a rigorous ECM remodeling modulated by MMP/RECK balance. Journal of Molecular Histology, v. 40, n. 3, p. 201-207, . (07/00216-2, 99/10655-5, 07/04148-1, 01/10707-7)

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