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ENANTIOSELECTIVE SYNTESIS OF CENTRAL STRUCTURE OF SOME INHIBITORS OF HIVPR BY BIOTRANSFOMATION OF SUBSTITUTED ENONES.

Grant number: 09/14913-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2010
Effective date (End): December 31, 2010
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Paulo José Samenho Moran
Grantee:Gabriela de Fátima Rossi Morais
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This project aims the chemi-enzimatic synthesis of optically active epoxyamine and epoxyazido used as chiral intermediaries in the synthesis of HIVPR inhibitors with hydroxiethylamine structure. The key step is the bioreduction of C=C and C=O by Saccharomyces cerevisiae or other microorganisms in the obtaintion of chiral centers in high enantimeric excess.

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