Cardiovascular diseases, as heart failure and hypertension, have great epidemiological outstanding in any worldwide health program and are characterized, among other action, by an enhancement of beta-adrenergic receptor stimulation. One experimental model used to mimetize this state is got by daily subcutaneously administration of isoproterenol, a non-selective beta-adrenergic agonist. Studies from our group demonstrated that this treatment can increase the response to vasoconstrictor agents, by an endothelial-dependent pathway on rat aorta. Nowadays, a local inflammatory process was associated with endothelial dysfunction and vascular reactivity alterations in some cardiovascular diseases, like atherosclerosis and hypertension. In particular, chronic beta-adrenergic receptor stimulation can increase the synthesis of pro-inflammatory cytokines in the heart and in the blood vessels of animals submitted to the treatment with isoproterenol, suggesting a relation among inflammation, chronic beta-adrenergic stimulation and vascular dysfuction. A great promising pathway with anti-inflammatory effects and which is able to improve vascular function involves the treatment with ligands of the nuclear receptors peroxissome proliferator-activated receptors or PPARs. Thus, the objective of this project will be to evaluate the effects of the PPAR-alpha; and -gamma; ligands on the vascular reactivity and its endothelial modulation of aorta rings from 7 day isoproterenol-treated rats.
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