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Chemical diversity, genetic polymorphism and pharmacological activities of Croton (Euphorbiaceae)

Grant number: 08/09942-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2009
Effective date (End): May 31, 2012
Field of knowledge:Biological Sciences - Botany - Applied Botany
Principal Investigator:Antonio Salatino
Grantee:Lucimar Barbosa da Motta
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

"Chemical diversity, genetic polymorphism and pharmacological activities of Croton (Euphorbiaceae)". Croton L. is the second largest genus of Euphorbiaceae, comprising about 1,300 species. Several Croton species have long been included among important medicinal plants in popular Brazilian traditions. Croton chemistry is widely diverse, a fact that qualifies the group as highly promising toward studies aiming prospects of pharmacologically active natural substances. The objective of the present project is to raise data about chemical composition of five species of Croton, by means of analyses by GC/MS and HPLC/MS of extracts containing alkaloids, diterpenes, volatile oils and flavonoids. It is intended also to evaluate the antioxidant, anti-bactericidal, anti-proliferative and anti-HIV1 activity of crude extracts and pure compounds from promising extracts. Because C. sphaerogynus shows morphological polymorphisms among different populations, it is an aim of the present project to detect possible chemical intra-specific polymorphisms, by establishment of chromatographic profiles and comparison among individuals from distinct populations. The results will be matched with data of comparative analyses using AFLP (amplified fragment length polymorphism) markers of the same individuals used in chemical analyses. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOTTA, LUCIMAR B.; FURLAN, CLAUDIA M.; SANTOS, DEBORAH Y. A. C.; SALATINO, MARIA L. F.; DUARTE-ALMEIDA, JOAQUIM M.; NEGRI, GIUSEPPINA; DE CARVALHO, JOAO E.; RUIZ, ANA LUCIA T. G.; CORDEIRO, INES; SALATINO, ANTONIO. Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 21, n. 6, p. 972-977, . (08/09942-0, 08/10595-3)

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