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Isolation, structural elucidation and biological activity of peptides of Jatropha curcas (Euphorbiaceae)

Grant number: 04/07062-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2004
Effective date (End): December 31, 2006
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Vanderlan da Silva Bolzani
Grantee:Wanessa Fernanda Altei
Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:98/05074-0 - Conservation and sustainable use of the plant biodiversity from the Cerrado and the Atlantic Forest: chemical diversity and prospecting for potential drugs, AP.BTA.TEM


The main goal of this project is to search for bioactive compounds from plants species occurring in the State of São Paulo, specially in the remanescent Cerrado and Atlantic forest. The screening of plant extracts by means of bioassays designed to detect potential anticancer, antioxidant, antifungal and antimalarial compounds will establish a model for further investments in this field in order to preserve, to study and to exploit rationally the remaining flora of São Paulo State. For some species selected in the screening, cell and tissue cultures will be developed to allow preservation of its germoplasm as a reliable source of renewable materials. Undifferentiated tissues will also be used as an alternative source of compounds and for biosynthesis and regulation studies of major secondary metabolites. (AU)

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