Advanced search
Start date

Analyis of genotypic profile of IL-10 and IL-18 genes in thyroid cancer patients

Grant number: 08/08463-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2009
Effective date (End): October 31, 2009
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Laura Sterian
Grantee:Lucas Leite Cunha
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Infiltrating lymphocytes and immature dendritic cells are usually found in well differentiated tumors like the papillary thyroid carcinoma. IL-10 cytokine controls the resolution of inflammation mainly regulating lymphocyte activation, dendritic cells and macrophages. IL-10 1082G allele produces more IL-10 than IL-10 1082A alelle. Interleukin-18 (IL-18) is a proinflammatory cytokine. Its promoter site has a polymorphism (+105A/C) whose function is still not clear but may be associated to immune response against cancer. The aim of this research is to investigate the influence of these polymorphisms on both the susceptibility and the outcome of well differenciated thyroid carcinomas.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: