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Role of the sodium bicarbonate on the radiocontrast agent induced nephropathy in rats.

Grant number: 10/01008-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2010
Effective date (End): April 30, 2011
Field of knowledge:Health Sciences - Nursing - Medical-Surgical Nursing
Principal Investigator:Maria de Fatima Fernandes Vattimo
Grantee:Juliana Guareschi dos Santos
Host Institution: Escola de Enfermagem (EE). Universidade de São Paulo (USP). São Paulo , SP, Brazil


This study will evaluate de renal function (RF) and the urinary peroxide and TBARS (oxidative stress markers) of rats treated with sodium bicarbonate (SB) and iodinated radiocontrast (RC), in order to investigate if the bicarbonate solution can prevent the nephrotoxicity of the IR. Wistar rats weighing 250-300g, treated once a day for 05 days with the agents described as follow will be used: Saline (control rats, will receive saline, intraperitoneal (ip), SB+Saline (SB 3mL/Kg,); RC (meglumin ioxitalamate + sodium ioxitalamate, 3ml/Kg, i.p., once a day); SB+RC (SB 3ml/kg, i.p, one hour before and one hour after IR the RC).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERNANDES VATTIMO, MARIA DE FATIMA; DOS SANTOS, JULIANA GUARESCHI. Protective effect of sodium bicarbonate on radiological contrast medium-induced nephropathy in rats. Revista da Escola de Enfermagem da USP, v. 47, n. 3, p. 714-719, . (10/01008-7)

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