Scholarship 07/04918-1 - Tropismo, HIV

Grant number:	07/04918-1
Support Opportunities:	Scholarships in Brazil - Scientific Initiation
Effective date (Start):	December 01, 2007
Effective date (End):	February 29, 2008
Field of knowledge:	Biological Sciences - Biochemistry - Molecular Biology

Principal Investigator:	Ester Cerdeira Sabino
Grantee:	Ana Maria Barros de Carvalho

Host Institution:	Hemocentro de São Paulo. Fundação Pró-Sangue. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Associated research grant:	04/15856-9 - Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos, AP.TEM


Abstract RESUME Background: Expression of HIV-1 coreceptors on the surface of various human cells is believed to influence the dynamics of viral tropism throughout the course of HIV-1 infection. There is a concern that CXCR4 co-receptor usage could provide an advantage for replication and transmission to drug-resistant strains. In this study we aimed to determine the prevalence of virus co-receptor usage in a cohort of recent HIV seroconverters in São Paulo, Brazil, and HIV subtypes.Methods: Genomic DNA will be exracted from blood samples of 110 HIV-1seroconverter. V3 loop amino acid sequences at the time of initial diagnosis will be analysed for prediction of coreceptor usage.

News published in Agência FAPESP Newsletter about the scholarship:
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