Scholarship 24/10864-7 - Leucemia-linfoma linfoblástico de células precursoras, Biologia molecu - BV FAPESP
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Evaluation of MRD in patients with BCR::ABL1 positive leukemia - Ph+ ALL subtypes

Grant number: 24/10864-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: December 01, 2024
End date until: November 30, 2025
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Patricia Yoshioka Jotta
Grantee:Manuela Alvarenga Gonçalves Vicinança
Host Institution: Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB). Campinas , SP, Brazil

Abstract

Acute Lymphoblastic Leukemia (ALL) is the cancer with the highest incidence in childhood, in which there is an uncontrolled proliferation of blasts in the bone marrow, most frequently affecting the B cell line. Leukemia has genetic factors related to leukemogenesis and, thus, to their molecular classification. Among them, we can highlight the translocation t(9,22) BCR::ABL1. With the advancement of molecular biology, new studies have been carried out on this translocation, in which the subtypes "CML-like", which is similar to the lymphoid blast crisis of chronic myeloid leukemia (CML), and "ALL-typical", which is positive for BCR::ABL1 and does not follow the "CML-like" patterns, were defined. This new classification allows for a more specific and effective treatment for each patient. In this context, the aim of this project is to subclassify patients with BCR::ABL1 ALL into "ALL-typical" or "CML-like" by comparing the MRD of fusion transcripts and Ig/TCR rearrangements, associating these subtypes with treatment response, and to analyze in vitro the resistance or sensitivity of each subtype to new available drugs. In the preliminary results of 6 samples of ALL positive for BCR::ABL1, it was possible to classify 4 samples as "CML-like" and 2 samples as "ALL-typical".

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