Scholarship 24/17002-0 - Microtomografia, Obesidade - BV FAPESP
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INFLUENCE OF OBESITY ON ROOT RESORPTION AND RATE OF ORTHODONTICALLY INDUCED TOOTH MOVEMENT: 3D ANALYSIS

Grant number: 24/17002-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: December 01, 2024
End date until: November 30, 2025
Field of knowledge:Health Sciences - Dentistry - Orthodontics
Principal Investigator:Maria Bernadete Sasso Stuani
Grantee:Isabella Fachini Gemignani
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Introduction: Orthodontic tooth movement triggers a sequence of cellular and molecular events in periodontal tissues, where there is local release of several inflammatory mediators that can lead to root resorption. By generating tension in the roots of anchorage teeth, the application of orthodontic forces can predispose to the onset of external root resorption (ERR) with consequent loss of root volume. Objective: To evaluate "in vivo" the effect of obesity on root resorption induced by orthodontic mechanical force in rats, through the use of microtomography. Material and Method: A total of 40 animals will be randomly distributed into two groups with 20 animals in each group, being the Obese Group (OG) and the Non-Obese Group (NOG). The hemimaxilla of each animal will be subjected to induced tooth movement (IDM) using a 7mm closed nickel-titanium spring for a period of 7 and 14 days, with the left hemimaxilla serving as control (CG). Obesity will be induced by providing a high-calorie diet for 8 weeks before the start of tooth movement. After the experimental period, the animals will be sacrificed and the specimens will be fixed in 10% formalin. Microtomographic analysis will be performed on the hemimaxillas to verify the root volume of the first molars and the rate of tooth movement. Statistical analysis will be performed using ANOVA followed by Tukey's post-test (p¿0.05) and Student's t-test to analyze the animals' body mass, degree of root resorption and tooth movement (p¿0.05).

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