Scholarship 23/18102-6 - Diarreia, Ganho de peso - BV FAPESP
Advanced search
Start date
Betweenand

Organic zinc supplementation and its association with sodium butyrate and its effects on performance, tissue gene expression, epigenome and health of pre-weaning calves

Grant number: 23/18102-6
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date until: November 01, 2024
End date until: October 31, 2026
Field of knowledge:Agronomical Sciences - Animal Husbandry - Animal Nutrition and Feeding
Principal Investigator:Márcia Saladini Vieira Salles
Grantee:Larissa Schneider Gheller
Host Institution: Instituto de Zootecnia. Agência Paulista de Tecnologia dos Agronegócios (APTA). Secretaria de Agricultura e Abastecimento (São Paulo - Estado). Nova Odessa , SP, Brazil

Abstract

The objective of this study is to evaluate organic zinc supplementation and its association with sodium butyrate on performance, tissue gene expression, epigenome and health of suckling calves. The experiment will be conducted at the experimental farm of the Instituto de Zootecnia in Ribeirão Preto/SP. 48 male Holstein calves will be used, from newborn to 64 days of the experiment, assigned in a randomized block design (weight and birth), subjected to the following treatments C) control (no supplementation); ZnS) supplementation with 130 mg/kg dry matter (DM) of organic zinc in the replacer; BC) supplementation with 3 g/kg DM of sodium butyrate in the concentrate in the basal diet; and ZnBC) supplementation with 130 mg/kg DM of organic zinc in the replacer and 3 g/kg DM of sodium butyrate in the concentrate. Animal performance was evaluated and blood was analyzed for ²-hydroxybutyrate, blood count, lactate, lactate dehydrogenase, zinc and copper, as well as eating behavior and incidence of infection. During weaning, the inflammatory profile will be measured using acute phase proteins and oxidative stress parameters. After weaning, 24 animals will be slaughtered and morphometric studies of the intestine and rumen, rumen fermentation parameters, gene expression and epigenome of the liver, jejunum and rumen, as well as zinc and copper levels in the liver will be performed. Organic zinc and sodium butyrate supplements have different effects on the animal organism, with zinc supporting the immune system and butyrate supporting the digestive system. It is hoped that the combination of these supplements can result in a series of actions in the metabolism of calves, improving the productivity of suckling calves.

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list using this form.