Scholarship 24/06561-9 - Anticorrosivos, Micronúcleo - BV FAPESP
Advanced search
Start date
Betweenand

Genotoxic evaluation of anticorrosive compounds in Perna Perna mussels

Grant number: 24/06561-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: July 01, 2024
End date until: June 30, 2025
Field of knowledge:Biological Sciences - Ecology
Principal Investigator:Ana Carolina Feitosa Cruz
Grantee:Flávia Apolinário Galera
Host Institution: Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil

Abstract

Corrosion is the deterioration of metals through electrochemical processes and has been a major problem faced by the marine equipment and installations industry around the world. In order to prevent corrosion, some techniques can be applied, mainly the use of anti-corrosive paints. However, anticorrosives can present toxicity to marine organisms, making necessary more environmentally friendly alternatives. Among them are the organic anticorrosives, which have lower toxicity compared to inorganic inhibitors, in addition to offering equal or superior performance. Studies indicate that sodium gluconate (SG) has considerable corrosion inhibition capacity, in the same way as sodium nitrite (NO2). The encapsulation of SG and NO2 in double-layer hydroxides containing Zn-Al (Zn-Al LDH) is a strategy that has been developed and aims to avoid direct interaction between paint formulations and enable a more controlled release into the environment. This present work aims to evaluate the genotoxic effects of bio-based anticorrosive components (SG and NO2) free and encapsulated in the innovative Zn-Al LDH nanomaterial through the micronucleus test in mussels of the Perna Perna species. This species is recognized as an excellent biological model for biomonitoring and identification of genotoxic effects in marine organisms. Adult individuals will be acquired from a commercial cultivation, acclimatized to controlled laboratory conditions, and exposed to the compounds of interest, in free and nanoencapsulated forms, in concentrations between 0.3 mg/L and 10 mg/L. After 96 hours and 14 days of exposure, the hemolymph will be removed, and the cells will be fixed on glass slides, stained and analyzed for the presence of micronuclei (MN) and nuclear anomalies (NA), to evaluate the genotoxic effects of the compounds. After counting the cells under a microscope, the MN and NA rates will be calculated, and the data will be compared using analysis of variance followed by Dunnett's test. The study will provide important information for the development of these new anti-corrosive nanomaterials.

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list using this form.