Scholarship 24/05264-0 - Inflamação, Piper nigrum - BV FAPESP
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The nanopiperine effects on proliferation and migration in head and neck cancer cells

Grant number: 24/05264-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: June 01, 2024
End date until: May 31, 2025
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Flávia Cristina Rodrigues Lisoni
Grantee:Ana Laura Reganhan Campassi
Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

Head and neck tumors are highly relevant in public health matters, and it has been proved that reducing inflammation is very important for reducing the neoplastic process that can lead to the formation of malignant tumors. Therefore, anti-inflammatory agents can be used to treat this kind of cancer, even though there may be side effects, which makes studying new types of substances necessary, including phytotherapy ones. Piperine, one of the compounds found in Piper nigrum (black pepper), has proven antitumorigenic and anti-inflammatory effects. However, it is necessary to study this compound encapsulated in nanocapsules: nanopiperine promises greater bioavailability and dissolution than piperine itself, thus being more efficient in possible complementary treatment for such types of cancer. Therefore, our study's objective is to evaluate the effect of nanopiperine as an antitumor product on the morphology, proliferation, and migration of head and neck cancer cells. For this to be possible, the cell lines HeP-2 (larynx squamous cell carcinoma) and SCC-25 (tongue squamous cell carcinoma) will be used and treated with nanopiperine in 7 different concentrations (5, 10, 20, 25, 50, 60, and 70 µg/mL) for 24 and 48 hours. After the treatments, the cells will be tested to analyze cell morphology, proliferation, and migration. We expect that, if compared to the isolated piperine, nanopiperine will cause a more significant effect and modulate biological processes on cell morphology, proliferation, and migration, resulting in a reduction in tumor progression and inflammation. Thus, with these results, nanopiperine could be applied to clinical trials aiming at its use in complementary treatment for head and neck cancer.

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