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EFFECTS OF THE APPLICATION OF PHOTOBIOMODULATION (PBM) AND PLATELET-RICH PLASMA (PRP) IN RATS WITH KNEE OSTEOARTHRITIS

Grant number: 23/13745-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2024
Effective date (End): April 30, 2025
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Ana Laura Martins de Andrade
Grantee:Anne Missrie
Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

Introduction: Knee osteoarthritis results in degradation of the cartilage of the underlying bone, its main signs being pain, morning stiffness and loss of function. To prevent the progression of this pathology, electrophysical and biological agents can be applied to stimulate symptom relief and delay the disease. Among them, the use of laser photobiomodulation (PBM) and platelet-rich plasma (PRP) are effective resources that can be better explored. Objective: To evaluate and compare the effects of PBM and PRP, combined or isolated, in an experimental knee osteoarthritis model in rats. Methods: An in vivo experiment will be carried out with 32 Wistar rats, in which an intra-articular injection of MIA will be applied to the right knee to induce KOA. Then, the rats will be randomly distributed into 4 groups, namely: Control Group, Laser Group, PRP Group and Laser + PRP Group. The application of the infrared laser will be 808 nm, with fixed parameters, and the PRP will be 50 µL of PRP in the intra-articular region (infiltration type) after preparation. Histological and immunohistochemical analyzes will be carried out to evaluate the modulation and repair capacity of the techniques. Statistical analysis: Prism 8 software (GraphPad, USA) will be used to perform statistical analyses. The significance level adopted will be 5% (pd0.05).

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