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Evaluate in situ of Gamma-oryzanol on the products of metabolism in skeletal muscles with oxidative and glycolytic capacity in the animals submitted to the consumption of western diet

Grant number: 24/04007-4
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): June 01, 2024
Effective date (End): September 30, 2024
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Camila Renata Corrêa
Grantee:Thiago Luiz Novaga Palacio
Supervisor: Alfonsina D'Amato
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Research place: Università degli Studi di Milano, Italy  
Associated to the scholarship:23/06451-6 - Metabolomic profile of skeletal muscle of rats submitted to the western diet and its alterations on the intervention with Gamma Oryzanol, BP.MS

Abstract

The literature reports that the consumption of western diet can trigger damage to skeletal muscles by several metabolic pathways. To preserve skeletal muscle tissue, the useof bioactive compounds has been tested. It is described that the Gamma- Oryzanol (³Oz) has great influence on the mechanisms involved in skeletal muscle metabolism. Even though these reports are already established, studies with ³Oz addressing ³ broad aspect investigating all metabolic pathways in skeletal muscle of animals submitted to the Western diet have not yet been performed. Therefore, the aim of this study is to improvethe therapeutic capacity of ³Oz in metabolic alterations present in muscle s with oxidative capacity (Soleus) and glycolytic (Extensor digitorum longus muscle (EDL)) of Wistar rats submitted to western diet consumption. Wistar rats (n=32) will be randomly distributed into two groups to receive, ad libitum, control diet (C, n= 16 animals) and diet rich in sugar and fat plus 25% sucrose in drinking water (HSF, n= 16) for 20 weeks to induce obesity. After this period the animals will be redistributed into 4 groups, receiving, ad libitum, control diet (C, n=8 animals), control diet + Gamma-oryzanol (C + ³Oz, n=8 animals), diet rich in sugar and fat (HSF, n=8 animals) and diet rich in sugar and fat + Gamma-oryzanol (HSF + ³Oz, n=8 animals) for 10 weeks. Gamma-oryzanol will beincreased to 0.5% in the feed. The consumption of the animals will be measured daily to evaluate the caloric intake and the weight measured weekly. Skeletal muscle tissue metabolites will be identified and quantified through metabolomics. The data will be presented by descriptive measures of position and variability and analysed by specific comparison tests.

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