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Synthesis, spectroscopic characterization and evaluation of the antiviral and antibacterial activities of new Cu(II) e Zn(II) complexes with Schiff bases derived from amantadine

Grant number: 23/14657-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2024
Effective date (End): December 31, 2024
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Pedro Paulo Corbi
Grantee:Letícia Carraro Zucato
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Aminoadamantanes constitute a set of molecules widely used in the synthesis of drugs for various treatments of diseases, such as those caused by the Influenza virus and in the treatment of Alzheimer's. In this scenario, our research group has synthesized complexes of Ag(I), Au(I), Pd(II) and Pt(II) with aminoadamantanes, in order to find new candidates for metallopharmaceuticals that present superior antiviral and/or antibacterial activities to free aminoadamantanes.Recently, the group described the synthesis of new Ag(I) and Pt(II) complexes with amantadine, which showed promising results regarding their antiviral and antibacterial biological activities. Furthermore, the literature describes studies with amantadine and rimantadine, derivatives of aminoadamantanes, in the synthesis of Schiff bases and the preparation of Cu(II), Zn(II) and Co(II) complexes, with emphasis on determining their compositions and structures.In this project, studies will be carried out on the synthesis and characterization of new Cu(II) and Zn(II) complexes with Schiff bases derived from amantadine. The Schiff bases will be prepared from methanolic solutions of free amantadine and the aldehyde of interest, and the complexes will be prepared from methanolic solutions of the Schiff bases and the metallic salts of copper and zinc. The complexes will be characterized by chemical and spectroscopic analyzes, while their antibacterial activities will be evaluated by disk diffusion studies (antibiograms) and by determining their minimum inhibitory concentrations (MIC) on Gram-positive and Gram-negative bacterial strains. Subsequently, the antiviral activities of the complexes will be evaluated against the virus that causes Chikungunya Fever by quantifying viral load by luminescence, following literature protocols already applied in the study of other metallic complexes prepared and published by our research group.

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