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Immunoregulatory role of extracellular vesicles from Candida albicans and Aspergillus fumigatus

Grant number: 24/01074-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2024
Effective date (End): February 28, 2026
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Fausto Bruno dos Reis Almeida
Grantee:Júlia Leão Froldi
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:21/06794-5 - Fungal extracellular vesicles: immunomodulation and cellular communication, AP.JP2

Abstract

Fungal infections are associated with around 1.6 million deaths per year, affecting more than 1 billion people. Among the main pathogenic fungi, Cryptococcus spp., Aspergillus spp. and Candida spp. are notable for their high mortality. Extracellular vesicles (EVs) are structures formed by a lipid bilayer that carry several biomolecules that play important roles in fungal pathophysiology. Understanding the role of fungal EVs in host immunomodulation is crucial for understanding fungal pathogenesis and, consequently, for developing new antifungal therapies. In this sense, we propose to better understand the role of fungal EVs produced by Candida albicans and Aspergillus fumigatus during immunomodulation. More specifically, we propose to evaluate the production of inflammatory mediators and the cellular activity of macrophages stimulated with fungal EVs, evaluating the importance of TLR2, TLR4 and Dectin-1 type receptors in the recognition of these EVs. These results may identify potential prophylactic and therapeutic targets.

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