LONG-TERM PROGNOSIS OF HEART FAILURE DUE TO AORTIC VALVE DISEASE IN WOMAN AND MEN

Abstract

Heart failure (HF) is associated with higher mortality in aortic valve disease, and dyspnea is the main symptom indicating surgical intervention in patients with significant aortic valve disease (AVD). However, little is known about differences in long-term prognosis and predictors of death in women and men.This retrospective study involves the analysis of a cohort composed of 726 patients diagnosed with aortic valve disease (AVD) at the HCFMUSP Heart Institute, covering the period from 2009 to 2022. The objective is to examine baseline data, including clinical characteristics and echocardiographic findings, to investigate mortality and predictors of all-cause death in women and men with heart failure (HF) associated with VAD.Several clinical parameters will be examined, covering age, drugs used, prevalence of comorbidities, and cardiac surgical interventions. We will investigate comorbidities such as aortic aneurysm, coronary artery disease, diabetes, chronic kidney disease, atrial fibrillation, myocardial infarction, and stroke. The study evaluates the use and doses of various medications, such as ACE inhibitors, angiotensin II receptor blockers, beta-blockers, spironolactone, thiazide and loop diuretics, and anticoagulants.The cardiac surgical interventions evaluated include valve replacement and pacemaker implantation. Echocardiographic data will include parameters such as left ventricular ejection fraction, left ventricular systolic diameter, and systolic pressure in the pulmonary artery.Echocardiographic data will be collected from patients undergoing initial echocardiograms and at the end of the study. Mortality will be obtained from medical or Federal Revenue Service registration records.The methodology employed comprises the use of the Kaplan-Meier (K-M) and Cox proportional hazards methods for the analysis of mortality rates and predictors of death.