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Analysis of the prostate secretome profile of young and older rats subjected to maternal protein restriction: the search for biomarkers of the developmental origin of prostate cancer

Grant number: 23/15137-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2024
Effective date (End): January 31, 2025
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:Luis Antonio Justulin Junior
Grantee:Marcelo Augusto Ribeiro
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The DOHaD (Developmental Origins of Health and Disease) approach seeks to establish a correlation between the incidence of diseases in adulthood and aging in light of the events suffered during the beginning of development. One of its most used models for DOHaD studies is the submission of rodents to maternal protein restriction (RPM). Experimental studies already demonstrate that it is responsible for delaying the development of the prostate and increasing the incidence of Prostate Cancer (PCa) with aging. One of the main problems in PCa studies is tracking molecules that indicate its development, as well as understanding the behavior and signaling exerted by the tumor in the microenvironment and systemically. Thus, the objective of this work will be to analyze the profile of the ventral prostate (VP) secretome of animals on postnatal day (PND) 21 and 540 that were subjected to RPM. To do this, we will use proteomic data (Santos et al, 2020) from the VP of Sprague Dawley rats that were divided into two experimental groups: CTR group (control, with a 17% protein diet, n=6) and GLLP (protein restriction during pregnancy and lactation, 6% diet, n=6), and who was euthanized on DPN 21 and 540 (generated in process FAPESP 2017/01063-7). From global data we will identify differentially expressed proteins (PDEs), and evaluate the potential of these molecules to be secreted, we will investigate the molecular and ontogenetic pathways associated with PDEs and seek to associate them with data from human patients with PCa and their prognostic value. in prostate tumorigenesis. With this work, we hope to identify molecules secreted by the PV of animals subjected to RPM and their potential role in the developmental origin of PCa.

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