Advanced search
Start date
Betweenand

BIOMATERIAL-BASED NERVE WRAPS FOR THE TREATMENT OF NERVE INJURIES

Grant number: 23/14524-3
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): March 01, 2024
Effective date (End): February 28, 2025
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Alexandre Leite Rodrigues de Oliveira
Grantee:Diego Noé Rodríguez Sánchez
Supervisor: Ali Khademhosseini
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Terasaki Institute for Biomedical Innovation, United States  
Associated to the scholarship:21/02727-1 - Biofabrication of nerve guidance conduits, BP.PD

Abstract

Peripheral nerve injuries commonly generate persistent sensory/motor deficits even after surgical repair. Biomaterials for the controlled release of neuroregenerative molecules provide a promising approach for regulating the microenvironment during nerve regeneration. In this study, nerve wraps from a natural-based bioink made of gelatin methacryloyl (GelMA) combined with Laponite nanoparticles and incorporating fibroblast growth factor-2 (FGF-2) will be cross-linked with visible light and manufactured by three-dimensional (3D) bioprinting. Rheological and mechanical properties, degradation and swelling of bioprinted structures will be evaluated. Biological characterization including viability, metabolic activity, and gene expression of neurotrophic factors and pro-myelination in S16 cells (Schwann cells) cultured on the construct will be evaluated. Afterward, printability (e.g., accuracy of bioprinting through control of dimensions), porosity, and ultrastructure of printed materials will be characterized. Biofabrication of nerve wraps using biomimetic biomaterials with controlled release of molecules critical for neuroregeneration could protect and accelerate the nerve regeneration after neurorrhaphy, thereby avoiding perineural fibrosis and improving Schwann cell proliferation and subsequently functional and electrophysiological recovery.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list using this form.