UNDERSTANDING THE IMPACT OF PHYSICAL EXERCISE, IN ADDITION TO DIFFERENT SUPPLEMENTATION MODELS, ON OSTEOKINES AND BONE STRENGTH ASSESSED BY QUANTITATIVE ULTRASOUND (QUS) IN ADOLESCENTS AND YOUNG ADULTS: A RANDOMIZED CONTROLLED TRIAL

Abstract

Bone health during growth can be followed by DXA, the main method to assess bone density. However, this method may present an important bias once size of bone significantly affects its result and bone changes in content and size may take long to be observed. In a context of nutritional and/ or exercise interventions, bone metabolism markers have provided a more acutely measurement of bone response to the intervention. Furthermore, quantitative ultrasound has been used to assess the bone strength independent of bone mineral density. Lastly, recent literature has demanded efforts to understand the effect of nutritional supplements added to physical exercise. Thus, the objective of the present study is to analyze the effect of a 16-week intervention of increased Greek yogurt consumption and whey protein on circulating markers of bone metabolism and inflammation in adolescents and young adult volleyball players of both sexes. Blood analysis of osteokines (PINP, OPG, CTX, sclerostin, RANKL) and other cytokines related to bone metabolism (IL6, IL10, TNF±, IGF-I, PTH, testosterone and estrogen) will be conducted in the laboratory of Dr. Klentrou in collaboration with Dr. Josse, from York University, and bone strength will be assessed by quantitative ultrasound.