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Identification of genetic determinants associated with cardiovascular diseases and new therapeutic approaches

Grant number: 23/14161-8
Support Opportunities:Scholarships in Brazil - Program to Stimulate Scientific Vocations
Effective date (Start): January 08, 2024
Effective date (End): February 27, 2024
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:José Eduardo Krieger
Grantee:Rafael Sidônio Gibson Gomes
Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Precision Medicine is an innovative clinical approach that seeks a comprehensive assessment of an individual's health by integrating a patient's clinical data with genetic, molecular, physiological, and environmental information to provide personalized treatment. Cardiology, among other fields, has benefited from advances in precision medicine, including large-scale genetic sequencing and omics studies. Genetic tests are becoming more accessible for evaluating patients with cardiovascular diseases, especially with the use of Next Generation Sequencing (NGS), a technique that has revolutionized medical genetics, allowing for the identification of new genes associated with diseases and correlations between genotype and phenotype. Therefore, the implementation of a precision medicine service focused on identifying genetic variants associated with cardiovascular diseases is the initial step towards individualized treatments and potential therapeutic targets. (AU)

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