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Low frequency sound waves to form Nevirapine co-crystals

Grant number: 23/08683-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2023
Effective date (End): November 30, 2024
Field of knowledge:Engineering - Chemical Engineering - Chemical Technology
Principal Investigator:Eduardo Rezende Triboni
Grantee:Gabriela Kaori Taneguti Ueno
Host Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil


The present proposal intends to study the synthesis of Nevirapine co-crystals under the influence of a low frequency acoustic field. This unprecedented experimentation will involve crystallization under acoustic amplitude (dB) and different frequencies (between 30 Hz and 100 Hz). For the co-crystallization the co-formers caffeine, benzoic acid, 3-hydroxy-benzoic acid, and 4-hydroxy-benzoic acid will be used. The characterization of the co-crysts will be done by X-Ray Diffraction, calorimetry and infrared and Raman spectroscopy. The materials will be compared with those obtained from other crystallization techniques.

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