Silk fibroin microparticles for drug encapsulation: synthesis and kinectic release assays.

Abstract

The search for new biomaterials has found new sources in nature. Very recently, fibroin, one of the two proteins that make up the silk produced by the "silkworm" (Bombyx mori) and which is responsible for its resistance, has been explored as a biomaterial due to several characteristics such as biocompatibility, adequate mechanical properties, degradability, processability and induction of cell growth. A range of materials can be generated from silk, such as hydrogels, fibers, sponges and films. Among the applications obtained with silk fibroin are the preparation of molds for the growth of bone tissue and ligaments such as the meniscus, molds for blood vessel grafts, transparent films for applications in photonics and biomedicine, among others. In this project we intend to prepare spherical fibroin microparticles for encapsulation of the drugs acyclovir and isoniazid. The particles will be characterized and the percentages of drugs that have been encapsulated will be determined, as well as experiments will be carried out to determine the drug release rate in saline solution. The use of controlled drug release mechanisms has several advantages. The more uniform release of the drug avoids peaks in concentration and absorption that can cause symptoms in the body, depending on the drug chosen. Furthermore, the extension of the release time allows a reduction in the time interval between ingestion or application of the medication by the patient.