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Contribution of adipose tissue compartments to oral vaccine response

Grant number: 23/04035-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2023
Effective date (End): May 31, 2025
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:Denise Morais da Fonseca
Grantee:Guilherme William da Silva
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:21/06881-5 - Gut-lung axis: understanding the immune dialogue between barrier tissues in the development of disease, AP.JP2


The intestinal mucosa is one of the largest areas of the body exposed to the external environment, where it needs to deal with microbial or diet-derived antigens. At the same time that it operates in the absorption of nutrients, it elaborates responses against pathogens and affords immunological tolerance to innocuous antigens aiming maintenance of homeostasis. Studies using models of infection or chronic inflammatory bowel disease indicate that other mechanisms can act to ensure homeostasis in mucosal tissues, such as adjacent visceral adipose tissues. Adipose compartments, such as mesentery and omentum, also act as memory cells reservoir after gastrointestinal infection episodes. This protective profile in the adjacent adipose tissues could act after oral immunization events. Results of our group and from the literature show that there is an inefficacy of oral vaccines during environmental enteropathy, but with the permanence of the elaboration of memory lymphocytes in the mesenteric lymph nodes. Therefore, in the present project, the goal is to elucidate the adipose compartments as a reservoir of memory cells derived from vaccines, especially oral vaccines, and to verify the protective role of the adipose compartments after oral immunization in homeostasis and in the context of environmental enteropathy.

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