Grant number: | 23/05476-5 |
Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
Start date until: | July 01, 2023 |
End date until: | May 31, 2024 |
Field of knowledge: | Health Sciences - Medicine - Surgery |
Principal Investigator: | Iuri Santana Neville Ribeiro |
Grantee: | Alessandra Buccaran Canto |
Host Institution: | Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
Abstract Among the different types of CNS tumors, gliomas are the common type of brain tumors originating from glial cells: astrocytes, oligodendrocytes and ependymal cells and are divided into subgroups by their histology and similarity of their cells with differentiated glial cells. Its pathophysiology is not clear in several aspects, whose most studied risk factors are the use of cell phones, ionizing radiation and the use of pesticides. Brain metastases are the most common cause of neurological complications of cancer and enable the spread of the disease to the Central Nervous System (CNS). The frequency of occurrence of metastases in patients with other types of cancers is challenging to estimate, both by discrepancies in autopsy data, as well as observational studies and epidemiological reports. The Cancer Institute of the State of São Paulo receives patients not only with gliomas, but with various types of cancer, which represents a population in evidence in the development of brain metastases. Justification: It is essential to know the clinical and epidemiological aspects of gliomas and brain metastases and especially to evaluate survival in developing countries because the studies currently available are scarce. Objectives: Analysis of the clinical and epidemiological profile of patients undergoing surgery for gliomas removal and brain metastasis at the Cancer Institute of the State of São Paulo from 2008 to 2022, to evaluate clinical and neurological complications of patients operated by gliomas and brain metastasis, to evaluate costs related to the treatment of brain tumor, identify the main predictors of unfavorable clinical outcomes in Oncologic Neurosurgery and evaluate factors that influence the survival of patients operated by gliomas and brain metastasis. Methodology: Retrospective cohort study, based on data analysis and medical records of patients who underwent surgery for gliomas and brain metastases at the Cancer Institute of the State of São Paulo (ICESP) from 2008 to 2022. Expected results: It is expected to establish the clinical and epidemiological profile of patients diagnosed with gliomas and brain metastases, who were operated from 2008 to 2022 in ICESP. In addition, with the specific objectives of the research, it is intended to define fundamental variables in the elaboration of public strategies that allow its more effective treatment, as well as higher quality and survival to patients. | |
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