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Interaction of mirsinoic acid with membrane models using Langmuir monolayers

Grant number: 23/07185-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2023
Effective date (End): August 31, 2024
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Luciano Caseli
Grantee:Ana Gabrieli Araujo dos Santos
Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
Associated research grant:18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis, AP.TEM

Abstract

In this project, we intend to study the action of mirsinoic acid, a compound with potential antimicrobial and antitumor activity, with Langmuir films of phospholipids, which will serve as cell membrane models. The phospholipids to be used will be dipalmitoylphosphatidyl phosphatidylcholine (DPPC) and dipalmitoyl phosphatidyl serine (DPPS), which will be co-spread with the bioactive. The interaction of the bioactive with the lipid monolayers will be evaluated through measurements of pressure isotherms and surface potential, Brewster angle microscopy, infrared spectroscopy, and surface rheology. The results will be evaluated from the perspective of possible biological implications, inferred from the effects caused by the bioactive on artificial membranes.

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