Advanced search
Start date

Evaluation of the bioactive, microbiological and physical-mechanical properties of glass ionomer cements modified with sodium trimetaphosphate and zinc oxide nanoparticles: an in vitro study

Grant number: 22/08068-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2023
Effective date (End): March 31, 2024
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Marcelle Danelon
Grantee:Letícia Gonçalves Oliveira
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The purpose of this study is to evaluate the effect of incorporation of zinc oxide nanoparticles (ZnONPs) and sodium trimetaphosphate microparticles (TMP) in resin-modified glass ionomer cement (RIMIC) on the physical-mechanical properties. Specimens of each material (n=6) will be made: 1) CIVMR without ZnONPs/TMP (Control); 2) CIVMR with 1.0 % ZnONPs; 3) CIVMR with 2.0% ZnONPs; 4) CIVMR with 14.0% TMP; 5) CIVMR with 1.0% ZnONPs and 14.0% TMP and 6) CIVMR with 2.0% ZnONPs and 14.0% TMP (% m/m). The physical-mechanical properties of the CIVMR will be determined: Diametric tensile strength (RTD), Compressive strength (CR), Surface hardness of the materials (DS), Surface roughness (SR), Fluoride release (F), degree of conversion and morphological analysis of the CIVMRs containing or not containing TMP-ZnONPs by scanning electron microscopy (SEM). The chemical composition of the samples will be established by energy dispersive X-ray spectroscopy (EDX). The activity on microbiological properties will be performed by Streptococcus Mutans adhesion test, biofilm assay and cell metabolism by MTT assay. For statistical analysis, the RTD, RC, DS, RS, F values will be considered as variables; the cytotoxicity assay will be performed in MDPC-23 odontoblast-like cells and quantified by the MTT method); and as a variation factor the type of CIVMR. The data will be submitted to normality and homoscedasticity tests to apply the statistical analysis best suited to the data distribution. The statistical program Sigmaplot® for Windows version 12.0 will be used, with significance at the 5% level.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: