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Effect of Prebiotics, Probiotics and Symbiotics Supplementation on the Gene Expression of Factors Regulating Lipogenesis and Hepatic Betaoxidation in Malnourished Rats

Grant number: 23/02971-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2023
Effective date (End): December 31, 2023
Field of knowledge:Health Sciences - Nutrition - Malnutrition and Physiological Development
Principal Investigator:Claudia Cristina Alves Pereira
Grantee:Julia Roberta Messias
Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil


Malnutrition is a public health problem that affects millions of people around the world. It's a clinical condition in which nutrient intake is inadequate to meet metabolic needs of the organism. In addition to causing damage to physical and cognitive development, malnutrition can also impair the regulation of metabolic processes, in addition to interfering with hepatic metabolism, by affecting the expression of regulatory genes of lipid metabolism.The present study aims to evaluate the effect of offering prebiotics, probiotics or symbiotics on the expression of genes related to beta-oxidation and hepatic lipogenesis in rats subjected to malnutrition.

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