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Bioaccessibility of phenolic compounds following in vitro gut fermentation of passiflora

Grant number: 23/01479-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2023
Effective date (End): June 30, 2024
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal Investigator:Neuza Mariko Aymoto Hassimotto
Grantee:Thaís Mie Ando de Mello Araujo
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07914-8 - FoRC - Food Research Center, AP.CEPID
Associated scholarship(s):23/12711-0 - Gut-derived catabolites of proanthocyanidin: AhR-mediated ligand activity in human intestinal cells, BE.EP.IC


The insertion of fruits from native species in the market can enhance the socio-economic development of the region, in addition to valuing Brazilian biodiversity. The fruits of native passion fruit are rich in bioactive compounds associated with the reduction of the incidence of obesity-associated comorbidities. Our research group has demonstrated that the fruits from P. tenuifila, a passion fruit native to the Brazilian Cerrado, are rich phenolic compounds, especially, proanthocyanidins, and its ingestion promotes the improvement of some cardiometabolic markers. Proanthocyanidins are not absorbed in their native form, but are extensively metabolized by the intestinal microbiota into several low molecular weight compounds, which are attributed to the biological action. However, since metabolization depends on the microbiota, disturbances in its composition can drastically affect its metabolization. Thus, the objective of this work is to study the metabolism of proanthocyanidins from P. tenuifila by the intestinal microbiota. For that, the phenolic compounds will be submitted to colonic fermentation in vitro, from feces of two distinct microbiota profiles, in addition to evaluating the prebiotic effect.

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