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Effects of combined training performed before treatment on strength, muscle mass and aerobic fitness on systemic inflammatory cytokines in women with breast cancer

Grant number: 23/02500-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2023
Effective date (End): March 31, 2025
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Miguel Soares Conceição
Grantee:Glenda Beatriz Brazão Buzaglo
Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil
Associated research grant:21/01424-5 - Effects of combined physical training in women with Breast Cancer submitted to chemotherapy, AP.JP


Introduction: Tumor growth and neoadjuvant treatment induce a degradation of muscle mass and cardiorespiratory fitness in women with breast cancer, due to a pro-inflammatory process induced by the tumor. This impairment in muscle mass and cardiorespiratory fitness may increase toxicity and decrease the effect of chemotherapy. Since performing strength training and aerobic training, called combined training (CT), is an efficient strategy to decrease systemic inflammation, increase muscle mass and cardiorespiratory fitness, TC should be started before chemotherapy to decrease its adverse effects. Thus, investigating the response of systemic inflammation, muscle mass and cardiorespiratory capacity after a period of physical training in patients with breast cancer is essential. For this, measures of inflammatory cytokines, muscle mass and cardiorespiratory capacity before and after a period of combined training will be evaluated immediately after the diagnosis and finalized before starting the treatment. Objective: To determine the effect of combined training, performed before treatment, on the profile of inflammatory cytokines, muscle mass and cardiorespiratory capacity in women with breast cancer.Methods: Assuming a sampling error of at most 10%, with a confidence interval equal to 95%, a minimum sample of 100 cases will be required. Thus, 100 women with breast cancer with indication for neoadjuvant chemotherapy will be allocated in one of the following groups: CT before chemotherapy (TC, n=50), or control group (GC, n=50). Then, these women will undergo, both before and after the CT period, the following assessments: 1) body composition by dual-energy X-ray absorptiometry (DXA); 2) muscular strength through the one repetition maximum test (1-RM); 3) aerobic fitness through the direct test of maximum oxygen consumption (VO2max); 4) functionality through the sit and stand and Timed Up and Go tests; 05) quality of life through the FACT-B questionnaire; 6) nutritional intake through food recalls; 7) blood and tumor collections for molecular analyses. Blood samples for molecular analyzes will be collected in 5 moments: 1st) before the first CT session; 2nd) immediately after the first CT session; 3rd) before the last CT session; 4th) immediately after the last CT session; 5th) 3 days after the 8 weeks of CT. CT will be performed 3 times a week. The TC protocol will consist of strength training (8 exercises, 1-3 sets of 8-12 RM at 80-90% of 1-RM and 2 min between sets) followed by aerobic training (3-4 sets of 3 min at 90% VO2max for 3 min of active recovery (30% of VO2max) on the cycle ergometer. Expected Results: It is expected that the increase in lean mass and aerobic fitness acquired by CT performed before chemotherapy is a determining factor in reducing pro-inflammation in women with breast cancer.

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