Scholarship 22/13352-1 - Biomateriais, Prótese vascular - BV FAPESP
Advanced search
Start date
Betweenand

Vascular prosthesis of nitric oxide donor micellar hydrogels

Grant number: 22/13352-1
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Start date until: April 01, 2023
Status:Discontinued
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Marcelo Ganzarolli de Oliveira
Grantee:Mateus Peres Bomediano
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release, AP.TEM
Associated scholarship(s):24/05080-7 - Incorporation of cholyl-nitroso-cysteine bile salts in Pluronic hydrogels: impact on the micellar packing, BE.EP.DD

Abstract

Thermoreversible micellar hydrogels of triblock copolymers of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) have aroused great interest in the field of biomaterials due to their biocompatibility. The main objective of this project is the development of photocrosslinkable PEO-PPO-PEO micellar hydrogels impregnated with polydopamine (PDA) nitric oxide (NO) donors for the fabrication of vascular prostheses by 3D printing. The copolymers will be chemically modified through the insertion of terminal vinyl groups. It is intended to describe and understand for the first time the effects of photocrosslinking and the extrusion process on the nanostructure of micelles and on the gelation process. It is also intended to obtain a synergistic action between the release of NO from incorporated S-nitrosothiols and the coating of prostheses with polidopamine, to obtain anti-thrombogenic and pro-endothelial blood contact surfaces, with prolonged release of NO. The micellar organization will be characterized by SAXS and Cryo-TEM. The micellization and gelation processes will be investigated by rheological tests and thermal analysis (DSC); the morphology of the surface and interior of the prostheses will be characterized by scanning electron microscopy (SEM-EDS); real-time NO release will be characterized by chemiluminescence and the mechanical properties of the prostheses will be evaluated by texturometry. Biological tests will include platelet adhesion assays and endothelial cell coating of prostheses. At the end of the project, it is intended to obtain an innovative biomaterial that can be used as a prosthesis in revascularization surgeries and for the irrigation of artificial organs. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list using this form.