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Postoperative analgesia of nalbuphine, by epidural route, in female dogs submitted to ovariohysterectomy

Grant number: 22/14047-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2023
Effective date (End): December 31, 2023
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Paulo Sergio Patto dos Santos
Grantee:Bianca Siqueira
Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The objective of this study is to evaluate the effectiveness of epidural nalbuphine for the postoperative analgesia in female dogs submitted to an elective ovariohysterectomy procedure. A total of twenty bitches aged from one to five years, weighing between 5 and 25 kg will be used in the study. The animals were divided into two experimental groups of 10 animals each, called control group (CG) and nalbuphine group (GN). All dogs received acepromazine (0.03 mg/kg) as preanesthetic medication (PAM) by the intramuscular route (IM). For anesthetic induction will be used propofol (dose-effect, IV), the animals will be intubated and connected to the anesthetic circuit, and kept under anesthesia with isoflurane. The collection of variables for the baseline moment will be performed before the epidural (M0), in the CG will be administered epidural anesthesia composed of morphine (0.1 mg/kg) and in the GN will be used nalbuphine (0.6 mg/kg), both will be diluted in 0.9% NaCl to a total volume of 0.22 mL/kg. The collection of the variables of interest in the transoperative period will start 10 minutes after the epidural administration (M1), immediately before the beginning of the surgery (M2), at the time of skin incision (M3), during the traction of the left pedicle (M4), traction of the right pedicle (M5), clamping of the uterine body (M6), beginning of muscle suture (M7) and end of dermorrhaphy (M8). In the postoperative period, the moments of interest will be measured at the time of extubation (Mextub), and after 60 and 120 minutes (M60, M120), and at two-hour intervals, for a total of 8 hours (M240, M360, M480, M600 and M720) and after 24 hours (M24). Postoperative analgesia will be evaluated in 5 ways by four evaluators, using pain scales (CMPS-SF, UMPS and numeric rating scale), von Frey filaments and abbreviated sedation scale, the need for rescue analgesia is determined by the agreement of two or more evaluators. For statistical analysis, the parameters evaluated will be submitted to the Shapiro-Wilk normality test, comparisons between groups will be evaluated by repeated measures analysis of variance (ANOVA) for non-parametric data (without normal distribution) and Tukey's test or Kruskal-Wallis (non-parametric data) and Dunn's test at each of the evaluation moments. The Pearson correlation will be performed, which will analyze the correlation between the evaluators for the pain scales and the abbreviated sedation scale.

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