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Selective peptide inhibitors for enzymes not fully neutralized by botropic antivenom: Surface Plasmon Resonance interaction studies

Grant number: 22/16608-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2023
Effective date (End): March 31, 2024
Field of knowledge:Health Sciences - Collective Health - Public Health
Principal Investigator:Sonia Aparecida de Andrade Chudzinski
Grantee:Samuel Forlani de Campos
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The objective of the present study is to evaluate in real time in Biacore T200 System (analytical method considered the gold standard), the interaction between human thrombin and human fibrinogen and if peptide inhibitors interfere in this interaction. Moreover, intends to elucidate the mechanism of inhibition of these peptides in relation to the botropic venom serinoproteases.

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